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When chemotherapy drugs are used alongside Hyperbaric Oxygen Therapy (HBOT), one notable risk is the increased risk of oxygen toxicity. This is mainly due to the heightened oxygen levels created during HBOT, which can lead to oxidative stress on tissues and organs. The presence of chemotherapy drugs can exacerbate this effect, as some agents may already have oxidative properties or may react negatively when combined with high levels of oxygen.

Oxygen toxicity can result in various side effects, including damage to the lungs, central nervous system complications, and other systemic issues. Understanding this risk is crucial for healthcare providers, as it necessitates careful monitoring and management of patients undergoing both treatments to prevent potentially severe adverse effects.

Enhanced oxygenation, improved wound healing outcomes, and minimized side effects are generally considered potential benefits of HBOT, but these do not specifically address the notable risks associated with its combination with chemotherapy. Thus, it is imperative to weigh the benefits against the risks when considering HBOT for patients who are also receiving chemotherapy.